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Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage.

The Andrej Karpathy episode.

During this interview, Andrej explains why reinforcement learning is terrible (but everything else is much worse), why AGI will just blend into the previous ~2.5 centuries of 2% GDP growth, why self driving took so long to crack, and what he sees as the future of education.

It was a pleasure chatting with him.

Watch on YouTube; read the transcript.

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Timestamps

(00:00:00) – AGI is still a decade away

(00:29:45) – LLM cognitive deficits

(00:40:05) – RL is terrible

(00:49:38) – How do humans learn?

(01:06:25) – AGI will blend into 2% GDP growth

(01:17:36) – ASI

(01:32:50) – Evolution of intelligence & culture

(01:42:55) - Why self driving took so long

(01:56:20) - Future of education

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Henry and Eddie bring you this week's weirdest stories and true-crime news starting off with "Suitcase Murderer" Sarah Boone seeking her 9th attorney after being reported for "difficult behavior", A man known as The Silent Man terrorizes UK by standing in crowded streets, Side Stories makes the news as Soup Gate 2024 continues, NJ Dad rips head off of Seagull at crowded beach, Listener E-Mails, and MORE!

Brendan Kane is a renowned digital strategist, author, and speaker who has built a name for himself by cracking the code on attention in the fast-paced world of social media. With a track record that includes pioneering YouTube influencer campaigns, developing digital platforms for icons like Taylor Swift and Rihanna, and generating over one million followers in just 30 days, Brendan is the go-to expert for understanding storytelling and growth in the digital space. His books, including "One Million Followers," "Hook Point," and "The Guide to Going Viral," have helped thousands master the art and science of authentic, scalable content creation. Brendan’s mission is to empower individuals and brands worldwide to stand out, connect meaningfully, and transform their visions into digital success.  Takeaways: Storytelling Is Everything: The foundation of social media success isn’t luck or fancy equipment—it’s mastering the art of storytelling through authentic formats that fit your personality and purpose. Start Where You Are, Master One Format: You don’t need to be a tech wizard or have celebrity status to make an impact. Focus on one content format or platform you resonate with, master it, and then consider diversifying. Social Media Is a Scalable, Accessible Tool: Whatever your business, message, or ambition—social media gives everyone the power to reach millions, drive impact, and even build billion-dollar brands, all with the phone in your pocket. Sound Bites: “It’s not about going viral for the sake of virality. True digital success is about the stories that connect people to who we are and what we stand for.” “If you can master authentic storytelling, it doesn’t matter if you’re a dentist or a rock star—you can build an audience and scale your business.” “Success on social isn’t about the platforms you post on, but about how powerfully you tell your story and why the world should care.” Connect & Discover Brendan: Website: https://brendanjkane.com/ YouTube: https://www.youtube.com/c/brendankane Facebook: https://www.facebook.com/BrendanJamesKane/ LinkedIn: https://www.linkedin.com/in/brendanjkane/ Book: The Guide to Going Viral Book: Hook Point Book: One Million Followers: How I Built a Massive Social Following in 30 Days 🔥 Ready to Unleash Your Inner Game-Changer? 🔥   Mick Hunt’s brand-new book, How to Be a Good Leader When You’ve Never Had One: The Blueprint for Modern Leadership, is here to light a fire under your ambition and arm you with the real-talk strategies that only Mick delivers.   👉 Grab your copy now and level up your life → Amazon, Barnes & Noble, Books A Million   FOLLOW MICK ON: Spotify: MickUnplugged Instagram: https://www.instagram.com/mickunplugged/ Facebook: https://www.facebook.com/mickunplugged/   YouTube:  https://www.youtube.com/@MickUnpluggedPodcast LinkedIn: https://www.linkedin.com/in/mickhunt/ Website:  https://mickhuntofficial.com/ Apple: MickUnplugged Learn more about your ad choices. Visit megaphone.fm/adchoices

NPR News: 11-13-2025 5PM EST

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P.M. Edition for Nov. 13. AI startup Anthropic said China’s state-sponsored hackers used its tools to automate cyberattacks against corporations and governments. WSJ’s Sam Schechner reports on the inflection point for hackers’ use of AI. Disney’s shares fell after a quarterly earnings report that fell short of Wall Street’s expectations. And California is eyeing a first-of-its-kind tax on billionaires. WSJ’s Paul Kiernan unpacks the ballot initiative for a wealth tax that’s already run into steep opposition. Sabrina Siddiqui hosts. Sign up for the WSJ's free What's News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Americans could soon lose access to Italian-made pasta due to a 107% tariff plan on pasta imports. WSJ's Margherita Stancati unravels how a fight over paperwork spiraled into a full-blown pasta war. Jessica Mendoza hosts.   Further Listening: - How One Business Owner Is Getting Ahead of Trump's Tariffs  - The Bean at the Center of the Trade War Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

NPR News: 11-13-2025 4PM EST

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