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a16z Podcast

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage.
00:45:21November 6, 2025
Dwarkesh Podcast

Andrej Karpathy — AGI is still a decade away

The Andrej Karpathy episode.

During this interview, Andrej explains why reinforcement learning is terrible (but everything else is much worse), why AGI will just blend into the previous ~2.5 centuries of 2% GDP growth, why self driving took so long to crack, and what he sees as the future of education.

It was a pleasure chatting with him.

Watch on YouTube; read the transcript.

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Timestamps

(00:00:00) – AGI is still a decade away

(00:29:45) – LLM cognitive deficits

(00:40:05) – RL is terrible

(00:49:38) – How do humans learn?

(01:06:25) – AGI will blend into 2% GDP growth

(01:17:36) – ASI

(01:32:50) – Evolution of intelligence & culture

(01:42:55) - Why self driving took so long

(01:56:20) - Future of education



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02:25:19October 17, 2025
Mick Unplugged

Brendan Kane: Dominate Social Media with Actionable Tips & Storytelling Mastery

Brendan Kane is a renowned digital strategist, author, and speaker who has built a name for himself by cracking the code on attention in the fast-paced world of social media. With a track record that includes pioneering YouTube influencer campaigns, developing digital platforms for icons like Taylor Swift and Rihanna, and generating over one million followers in just 30 days, Brendan is the go-to expert for understanding storytelling and growth in the digital space. His books, including "One Million Followers," "Hook Point," and "The Guide to Going Viral," have helped thousands master the art and science of authentic, scalable content creation. Brendan’s mission is to empower individuals and brands worldwide to stand out, connect meaningfully, and transform their visions into digital success.  Takeaways: Storytelling Is Everything: The foundation of social media success isn’t luck or fancy equipment—it’s mastering the art of storytelling through authentic formats that fit your personality and purpose. Start Where You Are, Master One Format: You don’t need to be a tech wizard or have celebrity status to make an impact. Focus on one content format or platform you resonate with, master it, and then consider diversifying. Social Media Is a Scalable, Accessible Tool: Whatever your business, message, or ambition—social media gives everyone the power to reach millions, drive impact, and even build billion-dollar brands, all with the phone in your pocket. Sound Bites: “It’s not about going viral for the sake of virality. True digital success is about the stories that connect people to who we are and what we stand for.” “If you can master authentic storytelling, it doesn’t matter if you’re a dentist or a rock star—you can build an audience and scale your business.” “Success on social isn’t about the platforms you post on, but about how powerfully you tell your story and why the world should care.” Connect & Discover Brendan: Website: https://brendanjkane.com/ YouTube: https://www.youtube.com/c/brendankane Facebook: https://www.facebook.com/BrendanJamesKane/ LinkedIn: https://www.linkedin.com/in/brendanjkane/ Book: The Guide to Going Viral Book: Hook Point Book: One Million Followers: How I Built a Massive Social Following in 30 Days 🔥 Ready to Unleash Your Inner Game-Changer? 🔥   Mick Hunt’s brand-new book, How to Be a Good Leader When You’ve Never Had One: The Blueprint for Modern Leadership, is here to light a fire under your ambition and arm you with the real-talk strategies that only Mick delivers.   👉 Grab your copy now and level up your life → Amazon, Barnes & Noble, Books A Million   FOLLOW MICK ON: Spotify: MickUnplugged Instagram: https://www.instagram.com/mickunplugged/ Facebook: https://www.facebook.com/mickunplugged/   YouTube:  https://www.youtube.com/@MickUnpluggedPodcast LinkedIn: https://www.linkedin.com/in/mickhunt/ Website:  https://mickhuntofficial.com/ Apple: MickUnplugged Learn more about your ad choices. Visit megaphone.fm/adchoices
00:43:51September 1, 2025
Last Podcast On The Left

Side Stories: The Silent Man

Henry and Eddie bring you this week's weirdest stories and true-crime news starting off with "Suitcase Murderer" Sarah Boone seeking her 9th attorney after being reported for "difficult behavior", A man known as The Silent Man terrorizes UK by standing in crowded streets, Side Stories makes the news as Soup Gate 2024 continues, NJ Dad rips head off of Seagull at crowded beach, Listener E-Mails, and MORE!
01:07:54August 1, 2024
Last Podcast On The Left

Side Stories: Do AI-Powered Coffee Machines Have Wet Dreams?

Ben and Henry are back just shootin' the breeze. Topics include: Self-driving cars, Robert Pickton getting bullied, KISS. Just be cool.
00:34:52June 28, 2018
a16z Podcast

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

NEW
Adam D’Angelo (Quora/Poe) thinks we're 5 years from automating remote work. Amjad Masad (Replit) thinks we're brute-forcing intelligence without understanding it. In this conversation, two technical founders who are building the AI future disagree on almost everything: whether LLMs are hitting limits, if we're anywhere close to AGI, and what happens when entry-level jobs disappear but experts remain irreplaceable. They dig into the uncomfortable reality that AI might create a "missing middle" in the job market, why everyone in SF is suddenly too focused on getting rich to do weird experiments, and whether consciousness research has been abandoned for prompt engineering. Plus: Why coding agents can now run for 20+ hours straight, the return of the "sovereign individual" thesis, and the surprising sophistication of everyday users juggling multiple AIs.
01:02:44November 7, 2025
a16z Podcast

Seeing The Future from AI Companions to Personal Software

Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exposes why command-line AI interfaces are the new MS-DOS, explains how mini-apps will become as shareable as TikToks, and details her decade-long journey from training language models in 2012 to building the platform where your mom can create custom apps in minutes. Plus: untold stories from OpenAI's apartment days and why voice-only devices completely miss the point.
00:50:20November 5, 2025
Last Podcast On The Left

Side Stories: Heist Stories

Henry & Eddie bring you this week's biggest stories and wildest news - Ghost Adventures puts Aaron Goodwin's personal life on blast in haunting new episode footage, The Louvre on lockdown after elaborate hundred-million-dollar "Crowned Jewel heist", Trio of Upstate NY teens use boat to allegedly raid & vandalize amusement park before making off with 200 stuffed animals, new leaks reveal shady transfers and cover-up activity surrounding Ghislaine Maxwell in prison, Private Contactor claims responsibility for series of New Jersey drone sightings, "Non-offending pedophile" storms stage, points gun at own head during NYC Wikipedia conference, 2 tragic deaths rock the Rock & Roll world, UFO The Movie LIVES, Listener E-Mails that amuse, and MORE!
01:12:30October 22, 2025
Planet Money

A new experiment in remote work … from the inside

NEW
When people in Maine prisons started getting laptops to use in their cells for online classes and homework, it sparked this new idea. Could they have laptops in their cells to work remotely for real outside world jobs, too??? And get real outside world wages?


Today on the show, we have reporting from Maine Public Radio’s Susan Sharon about a new experiment in prisons: remote jobs … paying fair market wages, for people who are incarcerated. 


Listen to Susan’s original reporting here: 


- In Maine, prisoners are thriving in remote jobs and other states are taking notice 

- Cracking the code: How technology and education are changing life in Maine prisons 


Related episodes:

- Fine and Punishment  

- Getting Out Of Prison Sooner 

- The Prisoner's Solution 

- Paying for the Crime 


Pre-order the Planet Money book and get a free gift. /  Subscribe to Planet Money+


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This episode was hosted by Sarah Gonzalez with reporting from Susan Sharon. It was produced by Sam Yellowhorse Kesler with reporting help from Vito Emanuel. It was edited by Jess Jiang, fact-checked by Sierra Juarez, and engineered by Robert Rodriguez, with help from Patrick Murray. Alex Goldmark is Planet Money’s executive producer. 

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00:28:16November 7, 2025
a16z Podcast

ElevenLabs CEO: Why Voice is the Next AI Interface

ElevenLabs CEO and co‑founder Mati Staniszewski joins Jennifer Li to explain how the team ships research‑grade AI at lightning speed—from text‑to‑speech and fully licensed AI music to real‑time voice agents—and why voice is the next interface for human‑computer interaction. He shares the small, autonomous team model, global hiring approach, and how the Voice Marketplace has paid creators over $10M while evolving into an enterprise platform.
00:30:50November 5, 2025
NPR News Now

NPR News: 11-07-2025 5PM EST

NEW
NPR News: 11-07-2025 5PM EST

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00:04:40November 7, 2025
a16z Podcast

Ben Horowitz and Ali Ghodsi: How to Run a Billion-Dollar Business

Ben Horowitz founded Loudcloud in the middle of the dot-com bust and sold it for $1.6 billion, then led Andreessen Horowitz from its founding to $46 billion in committed capital. Ali Ghodsi co-founded Databricks, stepped in as CEO during a crisis, and led it to a valuation of over $100 billion. In this episode of “Boss Talk”, Ben and Ali join a16z General Partners Sarah Wang and Erik Torenberg to share founder war stories, how to hire and make deals, how to keep culture intense without burning employees out, and why founders should raise their ambitions even higher.
01:07:30October 15, 2025
a16z Podcast

David Sacks: AI, Crypto, China, Dems, and SF

David Sacks, White House AI and Crypto Czar, joins Marc, Ben, and Erik to explore what's really happening inside the Trump administration's AI and crypto strategy. They expose the regulatory capture playbook being pushed by certain AI companies, explain why open source is America's secret weapon, and detail the infrastructure crisis that could determine who wins the global AI race.
01:16:57November 3, 2025
Global News Podcast

The Global Story: The rehabilitation of Syria’s ex-jihadist president

NEW

After getting the red-carpet treatment at the UN in New York last week, the former al-Qaeda fighter who now leads Syria is about to hold an election. But is Syria’s new president, Ahmed al-Sharaa, really about to transition the country into democracy? Or does he have other plans? The BBC's senior international correspondent Orla Guerin joins us from Damascus, where she’s been speaking to Syrians about the country’s future.

With Asma Khalid in DC, Tristan Redman in London, and the backing of the BBC’s international newsroom, The Global Story brings clarity to politics, business and foreign policy in a time of connection and disruption. For more episodes, just search 'The Global Story' wherever you get your BBC Podcasts. . Producers: Cat Farnsworth and Valerio Esposito Executive producer: James Shield Mix: Travis Evans Senior News Editor: China Collins

00:27:34November 9, 2025
Dwarkesh Podcast

Richard Sutton – Father of RL thinks LLMs are a dead end

Richard Sutton is the father of reinforcement learning, winner of the 2024 Turing Award, and author of The Bitter Lesson. And he thinks LLMs are a dead end.

After interviewing him, my steel man of Richard’s position is this: LLMs aren’t capable of learning on-the-job, so no matter how much we scale, we’ll need some new architecture to enable continual learning.

And once we have it, we won’t need a special training phase — the agent will just learn on-the-fly, like all humans, and indeed, like all animals.

This new paradigm will render our current approach with LLMs obsolete.

In our interview, I did my best to represent the view that LLMs might function as the foundation on which experiential learning can happen… Some sparks flew.

A big thanks to the Alberta Machine Intelligence Institute for inviting me up to Edmonton and for letting me use their studio and equipment.

Enjoy!

Watch on YouTube; listen on Apple Podcasts or Spotify.

Sponsors

* Labelbox makes it possible to train AI agents in hyperrealistic RL environments. With an experienced team of applied researchers and a massive network of subject-matter experts, Labelbox ensures your training reflects important, real-world nuance. Turn your demo projects into working systems at labelbox.com/dwarkesh

* Gemini Deep Research is designed for thorough exploration of hard topics. For this episode, it helped me trace reinforcement learning from early policy gradients up to current-day methods, combining clear explanations with curated examples. Try it out yourself at gemini.google.com

* Hudson River Trading doesn’t silo their teams. Instead, HRT researchers openly trade ideas and share strategy code in a mono-repo. This means you’re able to learn at incredible speed and your contributions have impact across the entire firm. Find open roles at hudsonrivertrading.com/dwarkesh

Timestamps

(00:00:00) – Are LLMs a dead end?

(00:13:04) – Do humans do imitation learning?

(00:23:10) – The Era of Experience

(00:33:39) – Current architectures generalize poorly out of distribution

(00:41:29) – Surprises in the AI field

(00:46:41) – Will The Bitter Lesson still apply post AGI?

(00:53:48) – Succession to AIs



Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
01:06:22September 26, 2025
Apple News Today

The hidden dangers of being pregnant in America

NEW

From Apple News In Conversation: The United States has the highest maternal mortality rate among high-income nations — and, according to the CDC, more than 80% of maternal deaths are preventable. In her new book, Unbearable: Five Women and the Perils of Pregnancy in America, journalist Irin Carmon follows families as they navigate fertility struggles, pregnancy, birth, and loss within a health-care system that too often fails them. Carmon sat down with Apple News In Conversation host Shumita Basu to talk about how the history of maternal health care in the U.S. continues to shape the lives of pregnant people today.

00:24:37November 8, 2025
Planet Money

Two ways AI is changing the business of crime (Two Indicators)

Pre-order the Planet Money book here for your free gift. 

Our sister show, The Indicator, is chronicling the evolving business of crime for its Vice Week series. Today, we bring to you two cases of crime in the age of AI. 

First, cybercriminals are using our own voices against us. Audio deepfake scams are picking up against individuals but also against businesses. We hear from a bank on how they’re adapting defenses, and find out how the new defenses are a game of AI vs AI. 

Then, we move over to the stock market to witness AI market manipulation. A new breed of trading bots behave differently. They could collude with each other, even without human involvement or instruction, so researchers are asking how to think about blame, and regulation in a world of more sophisticated trading bots. That’s assuming regulators could even keep up with the tech in the first place. 

Indicator Vice Series 
Head to The Indicator from Planet Money podcast feed for the latest on the Indicator Vice Series including an episode on data breaches . If you don’t already subscribe, check it out. Each episode explains one slice of the economy connected to the news recently, always in 10 minutes or less. 

Subscribe to Planet Money+ 

Listen free: Apple Podcasts, Spotify, the NPR app or anywhere you get podcasts.

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This episode is hosted by Darian Woods, Adrian Ma, and Wailin Wong. These episodes of The Indicator were originally produced by Cooper Katz McKim and engineered by Robert Rodriguez. They were fact-checked by Sierra Juarez. Kate Concannon is The Indicator’s editor. Alex Goldmark is the Executive Producer. 

Music: NPR Source Audio - “Diamond High” 

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00:19:39October 8, 2025
The Headlines

The Big Elections to Watch This Week, and a Louvre Heist Update

Plus, squeezing in a marathon before your full-time job.
00:10:19November 3, 2025
NPR News Now

NPR News: 11-07-2025 1PM EST

NEW
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00:04:40November 7, 2025
The Journal.

Tesla Gives Elon Musk a $1 Trillion Pay Package

NEW
Shareholders at Tesla approved the most valuable pay package ever for Elon Musk in an effort to bring his attention back to the company. The CEO will have to hit a number of milestones to get the full value of the package, including shifting Tesla’s focus to developing robotaxis and humanoid robots. WSJ’s Becky Peterson breaks down the complicated plan with Jessica Mendoza. Further Listening:  Why GM Is Slamming the Brakes on EV Ambitions Why Elon Musk’s AI Chatbot Went Rogue Tesla Has a Problem: Elon Musk Sign up for WSJ’s free What’s News newsletter.  Learn more about your ad choices. Visit megaphone.fm/adchoices
00:17:39November 7, 2025