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The Joe Rogan Experience

2770 ep1K
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The Level Up Podcast w/ Paul Alex

1262 ep1K
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The a16z Show

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The Joe Rogan Experience
The Joe Rogan Experience

#2537 - David Sinclair

David Sinclair, AO, PhD, is a longevity scientist, Professor of Genetics at Harvard Medical School, author of the book "Lifespan: Why We Age—and Why We Don't Have To," and host of the "Lifespan" podcast.www.youtube.com/c/davidsinclairpodcast  www.simonandschuster.com/books/Lifespan/David-Sinclair/9781501191978  https://lifespan.com  https://davidasinclair.com Perplexity: Download the app or ask Perplexity anything at https://pplx.ai/rogan. Visit https://superpower.com/rogan for $20 off your membership. This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices
02:30:37Aug 7, 2026
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The a16z Show
The a16z Show

The Startups Rebuilding American Industry | The AD50

America’s defense, energy, manufacturing, and robotics booms are increasingly becoming one story: the rebuilding of the country’s industrial base. This year’s AD50 highlights the companies building across that stack, from critical materials and factories to the systems they ultimately power. a16z’s Erin Price-Wright and Connor Love join Elena Burger to unpack what has changed. They discuss how defense demand can help finance manufacturing capacity that ultimately serves much larger commercial markets, why AI is changing the economics of American factories, and how a new generation of founders is applying lessons from SpaceX, Tesla, Anduril, and Palantir to mining, energy, manufacturing, and defense. They also make the case that these companies are no longer simply important to America. With private capital increasingly willing to fund physical infrastructure and production before government demand is guaranteed, they can become some of the most valuable companies in the world.
00:50:21Oct 29, 2026
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The a16z Show
The a16z Show

OpenAI: When AI Agents Use Computers Faster Than You

AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work. Ari and James join a16z’s Seema Amble and Fabrizio Serafini to explain how computer-using agents are already navigating legacy ERPs, reconciling financial data, handling procurement, and operating software without APIs or custom integrations. They also discuss why the harness around the model can matter as much as model intelligence, how enterprises can set deterministic guardrails around agent behavior, and why computer use could simultaneously extend the life of legacy software and accelerate the arrival of new AI-native applications. Looking ahead, they make the case for a more proactive and fluid relationship with computers, where agents work in the background, collaborate with users in real time, and increasingly adapt to us rather than requiring us to learn how to use them.
00:45:19Oct 26, 2026
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This American Life
This American Life

891: The Test Case

Some people in this country think Antifa is a dangerous domestic terror organization. Some think that’s a complete myth. This week, we go to the federal trial where, for the first time, the government sets out to prove that Antifa is real. Zoe Chace reports.

Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.

(00:00:00) Prologue: Host Ira Glass tells the story of what happened at the Prairieland Detention Center in Alvarado, Texas. The government claims this was an attack by an Antifa cell. The defense says it was a protest gone awry. This argument goes to court in a first-of-its-kind trial. (7 minutes)

(00:07:00) Act One: Reporter Zoe Chace walks us through one of the worst days for the defense: all these guns. (5 minutes)

(00:13:51) Act Two: Zoe takes us through the testimony of the government’s Antifa expert. The defense team is optimistic that things are going well for them. (8 minutes)

(00:29:55) Act Three: Zoe goes to jail to talk with one of the cooperating witnesses for the prosecution, a former church lady named Lynette Sharp. She has a lot to say about the events in her life that led her to accept a plea deal and testify against her friends. (24 minutes)

(00:55:17) Act Four: The verdicts come in. (12 minutes)

Transcripts are available at thisamericanlife.org / This American Life privacy policy. / Learn more about sponsor message choices.

01:11:57Jul 13, 2026

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The a16z Show
The a16z Show

Inside Salesforce’s $100 Billion M&A Playbook | John Somorjai

What makes a startup worth acquiring when software has never been easier to build? Salesforce’s John Somorjai says the answer goes well beyond technology: the best acquisitions can accelerate a product roadmap, bring in exceptional talent, and put a startup in front of 15,000 Salesforce sales reps almost overnight. John joins a16z General Partner Alex Immerman to unpack the thinking behind nearly $100 billion in acquisitions during his tenure, from Slack and MuleSoft to a new generation of AI-native companies. They discuss Salesforce’s build-versus-buy framework, why outcome-based pricing is replacing seats in parts of enterprise software, and what founders should consider when deciding whether to sell. John also shares what can kill a deal during diligence, why he thinks parts of today’s venture market are overvalued, and how Salesforce Ventures is expanding from enterprise software into frontier AI and robotics.
00:49:00Nov 6, 2026
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TBPN
TBPN

NASDAQ Plunges As AI Stocks Sink, GTA 6, OpenAI’s Revenue Inflection | Diet TBPN

Diet TBPN delivers the best of today’s TBPN episode in 30 minutes. TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays 11–2 PT on X and YouTube, with each episode posted to podcast platforms right after.

Described by The New York Times as “Silicon Valley’s newest obsession,” the show has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.

TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com/

Follow TBPN: 
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https://www.youtube.com/@TBPNLive

00:30:57Nov 5, 2026
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TBPN
TBPN

The Market Cries Out for Help, Neocloud FUD, Strauss Zelnick Fires Back at Take-Two Slander

  • (01:04) - NASDAQ Plunges
  • (17:33) - Neocloud FUD
  • (17:38) - 𝕏 Timeline Reactions
  • (27:58) - Strauss Zelnick Fires Back at Take-Two Slander
  • (32:30) - 𝕏 Timeline Reactions


TBPN is made possible by:

Ramp - https://ramp.com

Public - https://public.com

Cisco - https://www.cisco.com

Console - https://www.console.com

CrowdStrike - https://www.crowdstrike.com

Figma - https://www.figma.com

MongoDB - https://www.mongodb.com

NYSE - https://www.nyse.com

Railway - https://railway.com

Shopify - https://www.shopify.com

Codex - http://openAI.com/codex


Follow TBPN: 

https://TBPN.com

https://x.com/tbpn

https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231

https://podcasts.apple.com/us/podcast/tbpn/id1772360235

https://www.youtube.com/@TBPNLive

00:53:10Nov 5, 2026
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The a16z Show
The a16z Show

The New CFO: How AI Is Rewriting the Finance Function | Figma CFO Praveer Melwani

AI is moving finance from reconciling what happened last month to helping decide what the business should do next. Figma CFO Praveer Melwani argues that the best finance teams are becoming builders themselves, automating repetitive work so they can spend more time understanding customers, running experiments, and shaping strategy. Praveer joins a16z’s Seema Amble and Ivan Makarov to share what that shift looks like inside Figma, from collections and expense analysis to M&A diligence, where the corp dev team now uses AI to prototype products and simulate how Figma leaders might challenge an investment memo. They discuss why AI “slop” is a real risk, how Figma decides what to build versus buy, and why successful internal experiments eventually need a centralized systems layer to turn one-off agents into reliable infrastructure. They also get into what this means for hiring the next generation of finance leaders. Praveer’s bar isn’t simply whether someone can use AI. It’s whether they can understand the business, interrogate the output, communicate clearly, and use automation without outsourcing their thinking.
00:50:57Nov 5, 2026