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The a16z Show
OpenAI: When AI Agents Use Computers Faster Than You
AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work.
Ari and James join a16z’s Seema Amble and Fabrizio Serafini to explain how computer-using agents are already navigating legacy ERPs, reconciling financial data, handling procurement, and operating software without APIs or custom integrations. They also discuss why the harness around the model can matter as much as model intelligence, how enterprises can set deterministic guardrails around agent behavior, and why computer use could simultaneously extend the life of legacy software and accelerate the arrival of new AI-native applications.
Looking ahead, they make the case for a more proactive and fluid relationship with computers, where agents work in the background, collaborate with users in real time, and increasingly adapt to us rather than requiring us to learn how to use them.
00:45:19Oct 26, 2026
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The Joe Rogan Experience
#2537 - David Sinclair
David Sinclair, AO, PhD, is a longevity scientist, Professor of Genetics at Harvard Medical School, author of the book "Lifespan: Why We Age—and Why We Don't Have To," and host of the "Lifespan" podcast.www.youtube.com/c/davidsinclairpodcast www.simonandschuster.com/books/Lifespan/David-Sinclair/9781501191978 https://lifespan.com https://davidasinclair.com
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02:30:37Aug 7, 2026
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The a16z Show
The Startups Rebuilding American Industry | The AD50
America’s defense, energy, manufacturing, and robotics booms are increasingly becoming one story: the rebuilding of the country’s industrial base. This year’s AD50 highlights the companies building across that stack, from critical materials and factories to the systems they ultimately power.
a16z’s Erin Price-Wright and Connor Love join Elena Burger to unpack what has changed. They discuss how defense demand can help finance manufacturing capacity that ultimately serves much larger commercial markets, why AI is changing the economics of American factories, and how a new generation of founders is applying lessons from SpaceX, Tesla, Anduril, and Palantir to mining, energy, manufacturing, and defense.
They also make the case that these companies are no longer simply important to America. With private capital increasingly willing to fund physical infrastructure and production before government demand is guaranteed, they can become some of the most valuable companies in the world.
00:50:21Oct 29, 2026
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The MeidasTouch Podcast
Trump’s Saturday Is Already a Disaster…
MeidasTouch host Ben Meiselas reports on Donald Trump’s disastrous Saturday morning, including reports of mid-level and junior staffers demanding pardons, mounting allegations of corruption and criminality, and early voting developments signaling trouble for Republicans. Meiselas also discusses concerns about Big Tech suppressing MeidasTouch and his new book, WTF America.
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00:25:22Oct 24, 2026
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The a16z Show
The New CFO: How AI Is Rewriting the Finance Function | Figma CFO Praveer Melwani
AI is moving finance from reconciling what happened last month to helping decide what the business should do next. Figma CFO Praveer Melwani argues that the best finance teams are becoming builders themselves, automating repetitive work so they can spend more time understanding customers, running experiments, and shaping strategy.
Praveer joins a16z’s Seema Amble and Ivan Makarov to share what that shift looks like inside Figma, from collections and expense analysis to M&A diligence, where the corp dev team now uses AI to prototype products and simulate how Figma leaders might challenge an investment memo. They discuss why AI “slop” is a real risk, how Figma decides what to build versus buy, and why successful internal experiments eventually need a centralized systems layer to turn one-off agents into reliable infrastructure.
They also get into what this means for hiring the next generation of finance leaders. Praveer’s bar isn’t simply whether someone can use AI. It’s whether they can understand the business, interrogate the output, communicate clearly, and use automation without outsourcing their thinking.
00:50:57Nov 5, 2026
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TBPN
Wall Street Soars, Midterms Shake Up AI Race, Prediction Markets Win | Diet TBPN
Diet TBPN delivers the best of today’s TBPN episode in 30 minutes. TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays 11–2 PT on X and YouTube, with each episode posted to podcast platforms right after.
Described by The New York Times as “Silicon Valley’s newest obsession,” the show has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.
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00:30:42Nov 4, 2026
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TBPN
Politics 101, Prediction Markets Win, FOGO | Apoorva Mehta, Alex Spiro, Anish Agarwal, Derek Blasberg
- (01:05) - Midterm Election Recap
- (04:19) - Prediction Markets Win
- (23:56) - 𝕏 Timeline Reactions
- (25:57) - FOGO
- (32:16) - Ferrari Raises Its Outlook
- (36:40) - EU Plans to Downgrade Art Risk
- (40:23) - Apoorva Mehta, co-founder and former CEO of Instacart and founder of Abundance, discusses Instacart’s resilience, its evolution from a widely doubted idea into a major public company, and the persistence behind its success. He also explores the future of long-running AI agents, agentic investing, and Abundance’s goal of using AI-driven capital allocation to build a highly valuable company that benefits humanity.
- (01:01:16) - Alex Spiro, a prominent Quinn Emanuel trial lawyer and former prosecutor who represents high-profile founders and celebrities, discusses handling complex public cases, building an authentic legal career, and AI’s potential to streamline litigation. He also reflects on his growing business ventures, partnership with Tom Brady, and the challenges of online misinformation.
- (01:34:05) - Anish Agarwal discusses his role as co-founder and CEO of Traversal, which builds an AI site reliability engineer that identifies and resolves failures in complex enterprise systems. He explains the company’s focus on Fortune 500 customers, usage-based model, growing integration with coding agents, and recent $120 million fundraise at a $1 billion valuation.
- (01:42:56) - Derek Blasberg discusses his work as a New York-based fashion writer and his new book on legendary photographer Richard Avedon. He explores Avedon’s influence on fashion, photography, and culture while reflecting on AI-generated imagery, creative originality, and the renewed value of physical art and in-person experiences.
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02:14:42Nov 4, 2026
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Founders
#439 How Eiichiro Oda Works
Eiichiro Oda is a relentlessly obsessive creative genius who has devoted nearly every waking hour of his adult life to building one of the most extraordinary fictional universes ever imagined.
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00:32:30Nov 4, 2026