Find shows
you love

David Sinclair, AO, PhD, is a longevity scientist, Professor of Genetics at Harvard Medical School, author of the book "Lifespan: Why We Age—and Why We Don't Have To," and host of the "Lifespan" podcast.www.youtube.com/c/davidsinclairpodcast  www.simonandschuster.com/books/Lifespan/David-Sinclair/9781501191978  https://lifespan.com  https://davidasinclair.com Perplexity: Download the app or ask Perplexity anything at https://pplx.ai/rogan. Visit https://superpower.com/rogan for $20 off your membership. This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices

A groundbreaking new study claims to have found a way for a fully paralyzed person to communicate entirely via thought. But as we learned in an episode earlier this year, the scientists behind it have a checkered past. This episode was produced by Miles Bryan, edited by Matt Collette, engineered by Efim Shapiro, fact-checked by Tori Dominguez and Laura Bullard, and hosted by Sean Rameswaram. Transcript at vox.com/todayexplained Support Today, Explained by making a financial contribution to Vox! bit.ly/givepodcasts Learn more about your ad choices. Visit podcastchoices.com/adchoices

If you buy Salesforce to avoid fixing a broken sales process, you fail. If you buy AI to avoid fixing a broken business, you fail faster.

The Andrej Karpathy episode.

During this interview, Andrej explains why reinforcement learning is terrible (but everything else is much worse), why AGI will just blend into the previous ~2.5 centuries of 2% GDP growth, why self driving took so long to crack, and what he sees as the future of education.

It was a pleasure chatting with him.

Watch on YouTube; read the transcript.

Sponsors

* Labelbox helps you get data that is more detailed, more accurate, and higher signal than you could get by default, no matter your domain or training paradigm. Reach out today at labelbox.com/dwarkesh

* Mercury helps you run your business better. It’s the banking platform we use for the podcast — we love that we can see our accounts, cash flows, AR, and AP all in one place. Apply online in minutes at mercury.com

* Google’s Veo 3.1 update is a notable improvement to an already great model. Veo 3.1’s generations are more coherent and the audio is even higher-quality. If you have a Google AI Pro or Ultra plan, you can try it in Gemini today by visiting https://gemini.google

Timestamps

(00:00:00) – AGI is still a decade away

(00:29:45) – LLM cognitive deficits

(00:40:05) – RL is terrible

(00:49:38) – How do humans learn?

(01:06:25) – AGI will blend into 2% GDP growth

(01:17:36) – ASI

(01:32:50) – Evolution of intelligence & culture

(01:42:55) - Why self driving took so long

(01:56:20) - Future of education

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.dwarkesh.com

MeidasTouch host Ben Meiselas reports on Donald Trump’s Monday going off the rails as he posts fake Denzel Washington endorsements, oil surges to $107 a barrel, and MAGA Mike Johnson insists the administration deserves straight A’s. Meiselas also breaks down Trump’s escalating attacks on Congresswoman Ilhan Omar and reports of a raid at her Washington, D.C., home as Trump grows increasingly desperate. Go to https://Quince.com/meidas for FREE shipping on your order and 365-day returns. Pre-order the new book from MeidasTouch, WTF America?!: The Way Out of This Hell and Back to Democracy, today: https://bit.ly/wtfamericayoutube Visit https://meidasplus.com for more! Remember to subscribe to ALL the MeidasTouch Network Podcasts: https://meidasnews.com/podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

(0:00) Martin Shkreli joins the Besties!

(0:55) Why quantum computing is a one-trick business and why he's betting against it

(7:42) The drugs big pharma sells too cheap and his journey from hedge fund trader to pharma

(11:37) AI, drug discovery, and who actually wins

(21:32) Brilliance and rule-breaking, the gifted-kid trap & what prison taught him

 

Thanks to our partners for making this possible!

 

IREN is a vertically integrated AI Cloud platform, delivering data centers, compute and software for AI training and inference. https://iren.com/

 

Oracle connects the data, applications, and infrastructure that turn AI into business outcomes—with the flexibility, choice, and control to optimize as AI evolves. http://oracle.com/ai

EY helps tech innovators scale from startup to exit to megacap. You build the future. We'll handle the rest. http://www.ey.com

 

Meta believes the future is for everyone. We're focused on giving every person the tools to reach their full potential and making sure the benefits of technology are distributed to all. http://www.meta.com

 

Keel Infrastructure owns the power, land, and connectivity that HPC and AI run on - backed by secured energy assets and established grid interconnections across North America. https://keelinfra.com/

 

Airwallex - Agentic Global Business Accounts. Open local accounts in 70+ countries to accept payments, earn yield, pay globally, and manage spend. http://airwallex.com

 

PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure, PayPal empowers consumers and businesses in approximately 200 markets to join and thrive in the global economy. For more information, visit https://www.paypal.com

 

Google for Startups connects founders with the right people, products, and best practices to help startups build faster and go further. https://startup.google.com/

 

Explore ideas, industries, and technologies worth understanding with Chamath every week on Learn with Me: https://research.socialcapital.com/allin

 

Follow the besties: 

https://x.com/chamath

https://x.com/Jason

https://x.com/DavidSacks

https://x.com/friedberg

 

Follow on X:

https://x.com/theallinpod

 

Follow on Instagram:

https://www.instagram.com/theallinpod

 

Follow on TikTok:

https://www.tiktok.com/@allin

 

Follow on LinkedIn: 

https://www.linkedin.com/company/allinpod

 

Intro Music Credit:

https://rb.gy/tppkzl

https://x.com/yung_spielburg

 

#allin #tech #news

MeidasTouch host Ben Meiselas reports on Iran's warning threatening $2 trillion worth of U.S. infrastructure as tensions escalate. Meiselas breaks down the reported strikes on four tankers in the Strait of Hormuz, Iran's latest missile, drone, and aircraft tests, and questions about whether Iranian diesel is being sold to the United States through Russia under Trump's diesel deal. Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast Cult Conversations: The Influence Continuum with Dr. Steve Hassan: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show The Ken Harbaugh Show: https://meidasnews.com/tag/the-ken-harbaugh-show Majority 54: https://www.meidastouch.com/tag/majority-54 On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

MeidasTouch host Ben Meiselas reports on Ukraine's strikes on three Russian Yandex data centers as Trump faces backlash over his diesel deal with Russia and shifting claims about an energy ceasefire. Meiselas breaks down Zelensky's response, Russia's attacks on Ukraine's energy grid—including the Kharkiv thermal power plant—and bipartisan congressional criticism of Trump's Russian diesel deal. Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast Cult Conversations: The Influence Continuum with Dr. Steve Hassan: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show The Ken Harbaugh Show: https://meidasnews.com/tag/the-ken-harbaugh-show Majority 54: https://www.meidastouch.com/tag/majority-54 On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices